People who take ibuprofen on a regular basis have a lower risk of developing Parkinson's disease, research suggests.
The drug is commonly used to ease aches and pains but US research, in Neurology journal, found it had an added benefit.
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Experts say it is too soon to recommend the drugs to protect against Parkinson's |
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In studies of more than 135,000 men and women regular users of ibuprofen were 40% less likely to develop Parkinson's.
However, experts say it is too early to say whether the
benefits of taking the drug outweigh the risk of side effects such as
gastrointestinal bleeding.
Heart attack
Scientists have suspected for some time that anti-inflammatory
drugs might help buffer against the disease but it was unclear which
ones in the family of non-steroidal anti-inflammatory drugs or NSAIDs
conferred a benefit.
This most recent study suggests it is ibuprofen alone that has an effect.
But like all NSAIDs, ibuprofen can cause worrying side effects, like an increased risk of gastrointestinal bleeding.
A recent study also linked ibuprofen taken daily for some years to a small increased risk of heart attack and stroke.
The findings relate to non-steroidal anti-inflammatory drugs
like ibuprofen prescribed long-term to treat painful conditions such as
arthritis.
For this reason experts say more work is needed to determine
whether the benefits of taking the drug more often would outweigh any
risks.
If it did, it could offer a new way of managing this incurable neurological condition.
Nerve cells
Lead researcher Professor Alberto Ascherio, of the Harvard
School of Public Health, said: "There is no cure for Parkinson's
disease, so the possibility that ibuprofen, an existing and relatively
non-toxic drug, could help protect against the disease is captivating."
In his study, funded by the Michael J Fox Foundation, men and
women who used ibuprofen two or more times a week reduced their risk of
Parkinson's disease by more than a third compared with those who
regularly used aspirin, acetaminophen, or other NSAIDs.
Dr Kieran Breen, director of Research and
Development at Parkinson's UK, said it was difficult to know exactly
what effect ibuprofen might be having on the death of nerve cells in the
brain, and how it might affect whether somebody will get Parkinson's.
But based on the findings of this latest study, he said there would seem
to be an interesting link.
He said: "We know that inflammatory changes in the brain may
be involved in the death of nerve cells which cause Parkinson's,
particularly in the early stages of the condition.
"We are currently funding research into this area ourselves at the University of Oxford."
As to why ibuprofen alone might have the desired effect, the
US researchers say it could be down to the fact that this drug has a
specific role in blocking a biological pathway of cell damage and death.
Parkinson's
- One person in every 500 has Parkinson's
- People with Parkinson's do not have enough of a chemical called dopamine because some nerve cells in their brain have died
- This causes the typical symptoms of tremor, rigidity and slowness of movements
- This latest research was funded by the Michael J Fox Foundation
- a charity set up by the US actor in a bid to find a cure for the
condition after being diagnosed himself with young-onset Parkinson's
By Michelle Roberts Health reporter, BBC News
Photo: SPL